Metabolic Fingerprinting in Toxicological Assessment Using FT-ICR MS
نویسندگان
چکیده
منابع مشابه
Metabolic Fingerprinting in Toxicological Assessment Using FT-ICR MS
Detection of the toxicity of a candidate compound at an early stage of drug development is an emerging area of interest. It is difficult to determine all of the effects of metabolism of a compound using traditional approaches such as histopathology and serum biochemistry. The goal of a metabolomics approach is to determine all metabolites in a living system, with the potential to detect and ide...
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The ability of FT-ICR MS to resolve isotopic variants of intact proteins for each of the charge states formed by electrospray ionization offers a sensitive, rapid method for detecting "low mass" heterogeneity, where this is defined as the presence of structural variants differing in mass by 2 Da or less. Such heterogeneity may reflect biological or chemical modifications of structure or may res...
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Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) has high resolution, so provides a viable method to characterize extremely complex mixtures. The molecular formulas of individual components are determined simply by accurate mass measurement. Here, recent advances in FT-ICR MS application to pe troleum derived heavy materials are reviewed after a brief introduction of the...
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ژورنال
عنوان ژورنال: Journal of Toxicologic Pathology
سال: 2010
ISSN: 0914-9198,1881-915X
DOI: 10.1293/tox.23.67